I think Oswalt has the best chance to do damage and shut down the Sox, giving the Astros an opening win as the series goes to Houston Tuesday night.
BUT, if the White Sox stay scrappy and do just enough to beat Oswalt, then I see a 4 game sweep, as Oswalt losing would tear the heart out of the Astros.
I'll stand by my original prediction of Sox in 6, because I still think Houston is a good and dangerous team. But man, a sweep would be VERY nice.